PD-1 Expression in HIV-Specific CD8+ T cells Before Antiretroviral Therapy Is Associated With HIV Persistence

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dc.contributor.authorGhiglione, Yanina
dc.contributor.authorTrifone, César
dc.contributor.authorSalido, Jimena
dc.contributor.authorRhodes, Ajantha
dc.contributor.authorRuiz, Maria
dc.contributor.authorPolo, María Laura
dc.contributor.authorSalomon, Horacio
dc.contributor.authorLaufer, Natalia
dc.contributor.authorSued, Omar
dc.contributor.authorLewin, Sharon
dc.contributor.authorTurk, Gabriela
dc.date.accessioned2024-05-23T23:49:53Z
dc.date.available2024-05-23T23:49:53Z
dc.date.issued2019-01
dc.descriptionFil: Sued O. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractBackground: The persistence of latently infected T cells remains the principal barrier to HIV cure. Understanding how the early immune responses shape persistence of HIV on antiretroviral therapy (ART) will be fundamental for potential eradication. Here, we aimed to determine the relationship between CD8+ T-cell function and phenotype before therapy and HIV persistence on ART. Methods: Blood samples from 29 individuals enrolled during primary HIV infection (at baseline and every 3 months up to 2 years post-ART initiation) were obtained. HIV-specific T-cell function and expression of the activation markers were evaluated before ART by flow cytometry. Cell-associated HIV DNA and unspliced (US)-RNA were quantified in purified CD4+ T cells by real-time polymerase chain reaction. Data were analyzed using nonparametric statistics. Results: Elevated immune activation, dominance of monofunctional CD8+ T cells, and skewed distribution of memory profile were observed before ART. After ART initiation, HIV DNA and US-RNA levels rapidly diminished, reaching a plateau by 30 weeks after ART. The proportion of baseline HIV-specific effector memory and terminal effector CD8+ T cells directly correlated with HIV DNA levels at 1 year after ART. A strong positive correlation was observed between the proportion of bulk and HIV-specific PD-1High CD8+ T cells measured before ART and HIV DNA at 1 year after ART. Conclusions: A higher proportion of terminally differentiated CD8+ T cells and increased PD1 expression were associated with HIV persistence on ART after treatment of primary infection. Thus, the quality of the early CD8+ T-cell immune response may serve as a predictor of HIV persistence on ART.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1097/qai.0000000000001887
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1407
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesJAIDS Journal of Acquired Immune Deficiency Syndromes;2019 Jan 1;80(1):1-6
dc.rightsopenAccesses_ES
dc.subjectHIVes_ES
dc.subjectT-Lymphocyteses_ES
dc.titlePD-1 Expression in HIV-Specific CD8+ T cells Before Antiretroviral Therapy Is Associated With HIV Persistencees_ES
dc.typeArticuloes_ES

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