HIV Viral Load Suppression in Adults and Children Receiving Antiretroviral Therapy—Results From the IeDEA Collaboration

Simple item page
dc.contributor.authorJiamsakul, Awachana
dc.contributor.authorAwachana, Azar
dc.contributor.authorAlthoff, Keri N
dc.contributor.authorCesar, Carina
dc.contributor.authorCortes, Claudia
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorDo, Viet Chau
dc.contributor.authorEley, Brian
dc.contributor.authorGill, John
dc.contributor.authorKumarasamy, Nagalingeswaran
dc.contributor.authorMachado, Daisy Maria
dc.contributor.authorMoore, Richard
dc.contributor.authorProzesky, Hans
dc.contributor.authorZaniewski, Elizabeth
dc.contributor.authorLaw, Matthew
dc.date.accessioned2024-05-23T23:50:03Z
dc.date.available2024-05-23T23:50:03Z
dc.date.issued2017-11-01
dc.descriptionFil: Cesar C. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.descriptionFil: Machado DM. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractMachadoes_ES
dc.description.abstractBackground Having 90% of patients on antiretroviral therapy (ART) and achieving an undetectable viral load (VL) is one of the 90:90:90 by 2020 targets. In this global analysis, we investigated the proportions of adult and paediatric patients with VL suppression in the first three years after ART initiation. Methods Patients from the IeDEA cohorts who initiated ART between 2010 and 2014 were included. Proportions with VL suppression (<1000 copies/mL) were estimated using: (i) strict intention-to-treat (ITT) – loss to follow-up (LTFU) and dead patients counted as having detectable VL; and (ii) modified ITT – LTFU and dead patients were excluded. Logistic regression was used to identify predictors of viral suppression at one year after ART initiation using modified ITT. Results A total of 35561 adults from 38 sites/16 countries and 2601 children from 18 sites/6 countries were included. When comparing strict with modified ITT methods, the proportion achieving VL suppression at three years from ART initiation changed from 45.1% to 90.2% in adults, and 60.6% to 80.4% in children. In adults, older age, higher CD4 count pre-ART, and homosexual/bisexual HIV exposure were associated VL suppression. In children, older age and higher CD4 percentage pre-ART showed significant associations with VL suppression. Conclusions Large increases in the proportion of VL suppression in adults were observed when we excluded those who were LTFU or had died. The increases were less pronounced in children. Greater emphasis should be made to minimise LTFU and maximise patient retention in HIV-infected patients of all age groups.
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1097/qai.0000000000001499
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1417
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesJAIDS Journal of Acquired Immune Deficiency Syndromes;76(3):p 319-329, November 1, 2017
dc.rightsopenAccesses_ES
dc.subjectHIVes_ES
dc.titleHIV Viral Load Suppression in Adults and Children Receiving Antiretroviral Therapy—Results From the IeDEA Collaborationes_ES
dc.typeArticuloes_ES

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1097QAI.0000000000001499.pdf
Size:
414.79 KB
Format:
Adobe Portable Document Format
Description:
10.1097QAI.0000000000001499_eng
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Articulos científicos