In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral‑therapy‑naïve HIV‑infected men who have sex with men
Date
2020-9
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Volume Title
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Abstract
Human immunodeficiency virus type 1 (HIV) primary drug resistance mutations (DRMs) influence the long-term therapeutic effects of antiretroviral treatment (ART). Drug-resistance genotyping based on polymerase gene sequences obtained by next-generation sequencing (NGS) was performed using samples from 10 ART-naïve HIV-infected men who have sex with men (MSM; P1-P10) from the acute/early to chronic stage of infection. Three of the 10 subjects exhibited the presence of major (abundance, ≥ 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A). Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2-20%) that emerged during the chronic stage but ephemerally.
Description
Keywords
HIV, antiretroviral treatment
Citation
Arch Virol . 2020 Dec;165(12):2915-2919. doi: 10.1007/s00705-020-04823-z. Epub 2020 Sep 25.