In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral‑therapy‑naïve HIV‑infected men who have sex with men

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dc.contributor.authorCevallos, Cintia
dc.contributor.authorCulasso, Andrés C. A.
dc.contributor.authorUrquiza, Javier
dc.contributor.authorOjeda, Diego
dc.contributor.authorSued, Omar
dc.contributor.authorFigueroa, María I.
dc.contributor.authorAvila, María M.
dc.contributor.authorDelpino, M. Victoria
dc.contributor.authorQuarleri, Jorge F.
dc.date.accessioned2024-05-21T13:37:38Z
dc.date.available2024-05-21T13:37:38Z
dc.date.issued2020-9
dc.description.abstractHuman immunodeficiency virus type 1 (HIV) primary drug resistance mutations (DRMs) influence the long-term therapeutic effects of antiretroviral treatment (ART). Drug-resistance genotyping based on polymerase gene sequences obtained by next-generation sequencing (NGS) was performed using samples from 10 ART-naïve HIV-infected men who have sex with men (MSM; P1-P10) from the acute/early to chronic stage of infection. Three of the 10 subjects exhibited the presence of major (abundance, ≥ 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A). Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2-20%) that emerged during the chronic stage but ephemerally.
dc.identifier.citationArch Virol . 2020 Dec;165(12):2915-2919. doi: 10.1007/s00705-020-04823-z. Epub 2020 Sep 25.
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1002
dc.relation.ispartofseriesArchives of Virology; 165
dc.subjectHIV
dc.subjectantiretroviral treatment
dc.titleIn vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral‑therapy‑naïve HIV‑infected men who have sex with men

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