Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression

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dc.contributor.authorFalivene, Juliana
dc.contributor.authorGhiglione, Yanina
dc.contributor.authorLaufer, Natalia
dc.contributor.authorSocias, Maria E.
dc.contributor.authorHolgado, Maria Pia
dc.contributor.authorRuiz, Maria
dc.contributor.authorMaeto, Cynthia
dc.contributor.authorFigueroa, Maria Ines
dc.contributor.authorGiavedoni, Luis D.
dc.contributor.authorCahn, Pedro
dc.contributor.authorSalomon, Horacio
dc.contributor.authorSued, Omar
dc.contributor.authorTurk, Gabriela
dc.contributor.authorGherardi, María Magdalena
dc.date.accessioned2024-05-23T10:10:10Z
dc.date.available2024-05-23T10:10:10Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics and 13 Elite controllers (ECs) were studied. The percentages of Th17 and Treg subsets were severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17/Treg imbalance compared to HDs, in concordance with higher frequencies of activated CD8+ T-cells (HLA-DR+/CD38+). Better clinical status (higher CD4 counts, lower viral loads and activation) was associated with higher Th17 and lower Treg levels. We found positive correlations between Th17 at baseline and anti-HIV CD8+ T-cell functionality: viral inhibitory activity (VIA) and key polyfunctions (IFN-γ+/CD107A/B+) at both early and later times p.i, highlighting the prognostic value of Th17 cells to preserve an effective HIV T-cell immunity. Th17/Treg ratio and the IL-17 relative mean fluorescence intensity (rMFI of IL-17) were also positively correlated with VIA. Taken together, our results suggested a potential link between Th17 and Th17/Treg ratio with key HIV-specific CD8+ T-cell responses against the infection.
dc.identifier.citationFalivene, J., Ghiglione, Y., Laufer, N. et al. Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression. Sci Rep 5, 11511 (2015). https://doi.org/10.1038/srep11511
dc.identifier.other10.1038/srep11511
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1031
dc.relation.ispartofseriesScientific Reports, 5
dc.subjectTh17
dc.subjectHIV-Specific CD8+ T-cell Responses
dc.subjectDisease Progression
dc.titleTh17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression

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