A dynamic interplay of circulating extracellular vesicles and galectin-1 reprograms viral latency during HIV-1 infection
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
HIV-positive individuals on antiretroviral therapy(art) have detectable cell-associated unspliced (ca-Us) HIV rNain cD4+ t-cells from blood which varies with time. additionally, werecently showed that circadian transcription factors, circadian Loco-motor output cycles Kaput (cLocK) and brain and Muscle arnt-likeprotein-1 (bMaL1), bind to the HIV Ltr and increase HIV transcrip-tion. We hypothesised that circadian rhythms exert transcriptionalcontrol on latent HIV.
Description
Keywords
HIV 1, post-cART initiation
Citation
Journal of Virus Eradication 5:10-11. DOI: 10.1016/S2055-6640(20)31039-6